Basic Laboratory Research Themes in Oncology
Molecular, Cellular & Structural Biology
Research into the molecular, cellular & structural biology of cells focuses on the processes involved in cellular function and their disruption in cancer development. This includes the study of the life cycle (cell division, differentiation, proliferation and death), structure and internal components of cells and investigation of their interaction with their internal and external environments.
This research theme includes study of the makeup and function of biologically important molecules such as DNA, RNA and proteins; including investigation of the mechanisms of DNA replication & repair, gene expression, genetic imprinting & epigenetics and analysis of genetic mutations. It also involves examination of the 3 dimensional structures of biological molecules (such as proteins and nucleic acids), how they acquire the structure they have and how alterations in their structures affect their interaction with other molecules within the cell.
Research projects within this thematic includes:
- Shankar Balasubramanian - Structure, Function and Recognition of Nucleic Acids
- James Brenton - Functional Genomics of Ovarian Cancer Laboratory
- Kevin Brindle - Molecular Imaging in Cancer
- Carlos Caldas - Breast Cancer Functional Genomics
- Jason Carroll - Understanding Estrogen Receptor Function in Breast Cancer
- Alison Dunning - Genome Wide Association Studies, Confirmation and Fine-Scale Mapping of Discovered Loci
- Helena Earl - Clinical and Translational Research in Breast and Gynaecological Cancers With the Aim of Individualising Cancer Treatments for Patients
- Paul Edwards - Chromosome Changes in Breast and Oesophageal Cancer
- Rebecca Fitzgerald - Gastro-oesophageal Cancers; Understanding Pathogenesis of Barrett’s Oesophagus and Oesophageal Adenocarcinomas in Order to Improve Disease Management and Patient Care
- Fanni Gergely - Centrosome Biology
- Vincent Gnanapragasam - Translational Prostate Cancer Group
- Tony Green - Haematopoietic Stem Cells and Leukaemia
- John Griffiths - Cancer MRI and MRS; Metabolomics Magnetic Imaging and Spectroscopy
- Laura Itzhaki - Integrating Biophysics into Medicine
- Kim Jensen - Regulation of Epidermal Homeostasis by Extracellular Stimuli
- Duncan Jodrell - Pharmacology and Drug Development Group
- Phil Jones - Stem Cells and Cancer
- Florian Markowetz - Computational Biology: Cancer Genetics & Genomics and Stem Cell Biology
- Gillian Murphy - Proteases and Tumour Micro-environment
- Adele Murrell - Epigenetics and Imprinting in Cancer
- Masashi Narita - Cellular Senescence and Tumour Suppression
- David Neal - Urological Research
- Duncan Odom - Regulatory Systems Biology Laboratory
- Paul Pharoah - The Genetic Epidemiology of Cancer
- Anna Philpott - Division versus Differentiation in Development and Disease
- Bruce Ponder - Genetic Susceptibility to Cancer
- Jacqueline Shields - Defining a Role for Lymphatics in the Developing Tumour Microenvironment
- John Stingl - Mammary Gland Stem Cell Biology
- David Tuveson - Tumour Modelling and Experimental Medicine (Pancreatic Cancer)
- Ashok Venkitaraman - Understanding Chromosomal Instability and Exploiting it for Cancer Therapy
- Fiona Watt - Epithelial Cell Biology (Skin)
- Doug Winton - Stem Cell Biology of the Intestine