Dr Charlie Massie
Websites
- CRUK Cambridge Centre: https://crukcambridgecentre.org.uk/users/charliemassie
- Massie Group website: http://www.molecularinformatics.org (link is external)
Graduate Students
Dr Charlie Massie is pleased to consider applications from prospective graduate students.
Research Interests
Publications
Pubmed journal articles - pubmed
Key publications
Massie CE, Mills IG, Lynch AG. The importance of DNA methylation in prostate cancer development. JSBMB 2016 pii:S0960-0760(16)30105-4.
Cooper CS, et al; ICGC Prostate Group. Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue. Nat Genet. 2015;47(4):367-72.
Massie CE, et al; UK Prostate ICGC Group. HES5 silencing is an early and recurrent change in prostate tumourigenesis. ERC 2015;22(2):131-44.
Pertega-Gomes N, ..., Massie CE. Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and
cellular phenotypes in prostate cancer. Oncotarget. 2015;6(25):21675-84.
Asim M, Massie CE, et al. Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target. JNCI 2015;108(5).
Chen E, Ahn JS, Massie CE, et al. JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response. PNAS 2014;111(42):15190-5.
Nangalia J, Massie CE, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. NEJM 2013;369(25):2391-405
Sharma NL, Massie CE, et al. The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man. Cancer Cell. 2013;23(1):35-47
Massie CE, et al. The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J. 2011;30(13):2719-33.