Matt Hoare currently co-leads the East of England service for hepatocellular carcinoma (HCC), seeing patients from across the region and contributing to numerous observational and interventional clinical trials in HCC. His research interests centre around the diseased liver microenvironment and why this drives carcinogenesis. He has defined the genomic consequences of chronic liver disease, allowing a deeper understanding of the burden of DNA damage and the clonal dynamics of cirrhotic nodules in CLD as well as an understanding of the cancerisation field effect that exists in CLD. These findings have the potential to be disruptive to our understanding of the pathogenesis of CLD, translate into novel biomarkers of prognosis in CLD and potentially actionable therapeutic targets.
