I am Deputy Head of Department, Professor of Breast Radiation Oncology, a National Institute of Health Research (NIHR) Research Professor, Cancer Research UK RadNet Cambridge Lead and Honorary Consultant in Clinical Oncology.
I am also Chair of the UK National Cancer Research Institute Breast Clinical Studies Early Disease Subgroup, Editor-in-Chief of Clinical Oncology journal and lead for Cancer Research UK RadNet Cambridge Radiation Research Centre of Excellence and a member of the Cancer Research UK Cambridge Centre Breast Research Programme.
My research aims are to provide breast cancer patients with the best chance of cure with least side effects, by personalising radiation techniques based on risk of recurrence. I am Chief Investigator of 4 clinical trials with linked translational research:
- IMPORT LOW: phase III randomised trial (RCT) investigating intensity modulated radiotherapy (IMRT) and partial breast radiotherapy in patients at low risk of recurrence – in follow up: 2018 patients recruited; 71 UK centres
- IMPORT HIGH: phase III RCT investigating dose-escalated IMRT for patients at higher risk of recurrence - in follow up: 2617 patients recruited; 77 UK centres
- PRIMETIME: prospective cohort investigating post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers – open: 45 UK centres to date
- NEO-RT: feasibility study investigating pre-operative breast IMRT in patients receiving neo-adjuvant hormonal treatment – open: 2 UK centres