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Genetic study provides the most comprehensive map to date of breast cancer risk

last modified Feb 20, 2020 12:28 PM

Alison Dunning
 
A major international study of the genetics of breast cancer has identified more than 350 DNA ‘errors’ that increase an individual’s risk of developing the disease. The team led by Alison Dunning states that these errors may influence as many as 190 genes.

The results, published in Nature Genetics, provide the most comprehensive map of breast cancer risk variants to date. The researchers involved, from over 450 departments and institutions worldwide, say the findings will help provide the most detailed picture yet of how differences in our DNA put some women at greater risk than others of developing breast cancer.

In this new study, researchers from hundreds of institutions worldwide collaborated to compare the DNA of 110,000 breast cancer patients with that of  90,000 healthy controls. By looking in much closer detail than was previously possible, they identified 352 risk variants. It is not yet clear exactly how many genes these target, but the researchers have identified 191 genes with reasonable confidence; fewer than one in five of these had been previously recognised.